Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease
Identifieur interne : 000A34 ( Main/Corpus ); précédent : 000A33; suivant : 000A35Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease
Auteurs : Cristine Alves Da Costa ; Claire Sunyach ; Emilie Giaime ; Andrew West ; Olga Corti ; Alexis Brice ; Stephen Safe ; Patrick M. Abou-Sleiman ; Nicholas W. Wood ; Hitoshi Takahashi ; Mathew S. Goldberg ; Jie Shen ; Frdric CheclerSource :
- Nature Cell Biology [ 1465-7392 ] ; 2009-11.
Abstract
Parkin, an ubiquitin ligase whose mutations are associated with early development of Parkinson's disease, possesses a RING domain, suggesting it can modulate transcription. Parkin represses the expression of p53 both in fibroblasts and mice brains, independently of its ligase activity, and patient brain samples exhibit high levels of p53.
Url:
DOI: 10.1038/ncb1981
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ISTEX:C676C95926166904C35FC41DA35F19CC55E260C2Le document en format XML
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W.</fnm><snm>Wood</snm><inits>N W</inits><orf rid="a5"></orf></au><au><fnm>Hitoshi</fnm><snm>Takahashi</snm><inits>H</inits><orf rid="a6"></orf></au><au><fnm>Mathew S.</fnm><snm>Goldberg</snm><inits>M S</inits><orf rid="a7"></orf></au><au><fnm>Jie</fnm><snm>Shen</snm><inits>J</inits><orf rid="a7"></orf></au><cau><fnm>Frédéric</fnm><snm>Checler</snm><inits>F</inits><orf rid="a1"></orf><corf rid="c2"></corf></cau><aff><oid id="a1"></oid><org>Institut de Pharmacologie Moléculaire et Cellulaire and Institut de NeuroMédecine Moléculaire, UMR6097 CNRS/UNSA, Équipe labellisée Fondation pour la Recherche Médicale</org>, <street>660 Route des Lucioles</street>, <zip>06560</zip>, <cty>Valbonne</cty>, <cny>France</cny>.</aff><aff><oid id="a2"></oid><org>Institute for Cell Engineering, Johns Hopkins University School of Medicine</org>, <cty>Baltimore</cty>, <st>MD</st> <zip>21287</zip>, <cny>USA</cny>.</aff><aff><oid id="a3"></oid><org>INSERM U679, Hôpital de la Pitié-Salpêtrière, 47 boulevard de l'Hôpital</org>, <zip>75013</zip> <cty>Paris</cty>, <cny>France</cny>.</aff><aff><oid id="a4"></oid><org>Center for Environmental & Genetic Medicine, Institute of Biosciences & Technology</org>, <cty>Houston</cty>, <cny>USA</cny>.</aff><aff><oid id="a5"></oid><org>Department of Molecular Neuroscience, Institute of Neurology</org>, <street>Queen Square</street>, <cty>London</cty> <zip>WC1N 3BG</zip>, <cny>UK</cny>.</aff><aff><oid id="a6"></oid><org>Brain Research Institute, University of Niigata</org>, <street>1-757 Asahimachi</street>, <cty>Niigata</cty> <zip>951-8585</zip>, <cny>Japan</cny>.</aff><aff><oid id="a7"></oid><org>Center of Neurological Diseases, Harvard Medical School</org>, <cty>Boston</cty>, <st>Massachusetts</st>, <cny>USA</cny>.</aff><caff><coid id="c1"></coid><email>acosta@ipmc.cnrs.fr</email></caff><caff><coid id="c2"></coid><email>checler@ipmc.cnrs.fr</email></caff></aug><hst><re year="2009" month="03" day="20"></re><acc year="2009" month="07" day="14"></acc><pubdate type="aop" year="2009" month="10" day="04"></pubdate></hst><edsumm type="standfirst" publish="aop"><title></title><p>Parkin, an ubiquitin ligase whose mutations are associated with early development of Parkinson's disease, possesses a RING domain, suggesting it can modulate transcription. Parkin represses the expression of p53 both in fibroblasts and mice brains, independently of its ligase activity, and patient brain samples exhibit high levels of p53.</p></edsumm><edsumm type="standfirst" publish="issue"><title></title><p>Parkin, an ubiquitin ligase whose mutations are associated with early development of Parkinson's disease, possesses a RING domain, suggesting it can modulate transcription. Parkin represses the expression of p53 both in fibroblasts and mice brains, independently of its ligase activity, and patient brain samples exhibit high levels of p53.</p></edsumm></fm></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="eng"><title>Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease</title></titleInfo><titleInfo type="alternative" lang="eng" contentType="CDATA"><title>Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Cristine Alves</namePart><namePart type="family">da Costa</namePart><affiliation>Institut de Pharmacologie Molculaire et Cellulaire and Institut de NeuroMdecine Molculaire, UMR6097 CNRS/UNSA, quipe labellise Fondation pour la Recherche Mdicale, 660 Route des Lucioles, 06560, Valbonne, France.</affiliation><affiliation>E-mail: acosta@ipmc.cnrs.fr</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claire</namePart><namePart type="family">Sunyach</namePart><affiliation>Institut de Pharmacologie Molculaire et Cellulaire and Institut de NeuroMdecine Molculaire, UMR6097 CNRS/UNSA, quipe labellise Fondation pour la Recherche Mdicale, 660 Route des Lucioles, 06560, Valbonne, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Emilie</namePart><namePart type="family">Giaime</namePart><affiliation>Institut de Pharmacologie Molculaire et Cellulaire and Institut de NeuroMdecine Molculaire, UMR6097 CNRS/UNSA, quipe labellise Fondation pour la Recherche Mdicale, 660 Route des Lucioles, 06560, Valbonne, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andrew</namePart><namePart type="family">West</namePart><affiliation>Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Olga</namePart><namePart type="family">Corti</namePart><affiliation>INSERM U679, Hpital de la Piti-Salptrire, 47 boulevard de l'Hpital, 75013 Paris, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexis</namePart><namePart type="family">Brice</namePart><affiliation>INSERM U679, Hpital de la Piti-Salptrire, 47 boulevard de l'Hpital, 75013 Paris, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stephen</namePart><namePart type="family">Safe</namePart><affiliation>Center for Environmental & Genetic Medicine, Institute of Biosciences & Technology, Houston, USA.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Patrick M.</namePart><namePart type="family">Abou-Sleiman</namePart><affiliation>Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nicholas W.</namePart><namePart type="family">Wood</namePart><affiliation>Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hitoshi</namePart><namePart type="family">Takahashi</namePart><affiliation>Brain Research Institute, University of Niigata, 1-757 Asahimachi, Niigata 951-8585, Japan.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mathew S.</namePart><namePart type="family">Goldberg</namePart><affiliation>Center of Neurological Diseases, Harvard Medical School, Boston, Massachusetts, USA.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jie</namePart><namePart type="family">Shen</namePart><affiliation>Center of Neurological Diseases, Harvard Medical School, Boston, Massachusetts, USA.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Frdric</namePart><namePart type="family">Checler</namePart><affiliation>Institut de Pharmacologie Molculaire et Cellulaire and Institut de NeuroMdecine Molculaire, UMR6097 CNRS/UNSA, quipe labellise Fondation pour la Recherche Mdicale, 660 Route des Lucioles, 06560, Valbonne, France.</affiliation><affiliation>E-mail: checler@ipmc.cnrs.fr</affiliation><role><roleTerm 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